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Transcriptional modulation of foreign gene expression in engineered somatic tissues

Research paper by D. Bohl, J.-M. Heard

Indexed on: 01 Mar '98Published on: 01 Mar '98Published in: Cell Biology and Toxicology



Abstract

Many diseases that are candidates for gene therapy require that the therapeutic gene expression level be controlled to ensure biological efficacy and to prevent toxic effects. Various systems have been described that allow transcriptional regulation by artificial chimeric transactivators in mammalian cells. This paper describes these various systems and discusses their interests for gene therapy.