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Transcription factor FIGLA is mutated in patients with premature ovarian failure.

Research paper by Han H Zhao, Zi-Jiang ZJ Chen, Yingying Y Qin, Yuhua Y Shi, Shan S Wang, Youngsok Y Choi, Joe Leigh JL Simpson, Aleksandar A Rajkovic

Indexed on: 24 May '08Published on: 24 May '08Published in: The American Journal of Human Genetics



Abstract

Premature Ovarian Failure (POF) is a genetically heterogenous disorder that leads to hypergonadotropic ovarian failure and infertility. We screened 100 Chinese women with POF for mutations in the oocyte-specific gene FIGLA and identified three variants in four women: missense mutation c.11C --> A (p.A4E) was found in two women; deletion c. 15-36 del (p.G6fsX66), resulting in a frameshift that leads to haploinsufficiency, was found in one woman; and deletion c.419-421 delACA (p.140 delN) was found in one. Functional analyses by the yeast two-hybrid assay demonstrated that the p.140 delN mutation disrupted FIGLA binding to the TCF3 helix-loop-helix (HLH) domain. Our findings show that a subset of Chinese women with sporadic, premature ovarian failure harbor mutations in FIGLA.