Toxins, Vol. 8, Pages 220: Impact of CDT Toxin on Human Diseases

Research paper by Tiphanie Faïs, Julien Delmas, Arnaud Serres, Richard Bonnet, Guillaume Dalmasso

Indexed on: 20 Jul '16Published on: 15 Jul '16Published in: Toxins


Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects.