Total synthesis of isofregenedadiol.

Research paper by Suresh E SE Kurhade, Abbas I AI Sanchawala, Velayutham V Ravikumar, Debnath D Bhuniya, D Srinivasa DS Reddy

Indexed on: 28 Jun '11Published on: 28 Jun '11Published in: Organic Letters


The first total synthesis of isofregenedadiol, a bicyclic diterpene isolated from H. Viscosum, is reported starting from a D-(-)-pantolactone chiral pool. A one-pot quadruple reaction sequence comprising an enyne ring-closing metathesis/cross-metathesis/Diels-Alder/aromatization for the construction of a target skeleton is the highlight of the present synthesis.