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Total syntheses of Prelactone V and Prelactone B

Research paper by S. Raghavendra, Krishnaji Tadiparthi, J.S. Yadav

Indexed on: 10 Mar '17Published on: 28 Feb '17Published in: Carbohydrate Research



Abstract

The total syntheses of natural products Prelactone-V and Prelactone-B have been accomplished by a novel Chiron approach starting from d-glucose. The synthesis involves isopropylidene acetal formation of d-glucose using Poly(4-vinylpyridine) supported iodine as a catalyst, Tebbe olefination, Grignard reaction, Wittig olefination, selective mono deprotection of acetal using PMA/SiO2, hydrogenation and anti-1,3-diol formation are as key steps.

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