Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis.

Research paper by Vera L G VL Calich, Adriana A Pina, Maíra M Felonato, Simone S Bernardino, Tania A TA Costa, Flávio V FV Loures

Indexed on: 04 Apr '08Published on: 04 Apr '08Published in: FEMS immunology and medical microbiology


The aim of this minireview is to present a concise view of the most important pattern recognition receptors used by the innate immune system to sense and control pathogen growth into host tissues. A brief review of the role of Toll-like receptors (TLRs) in fungal infections followed by some recent results on the function of TLR4, TLR2 and the MyD88 adaptor molecule in the pathogenesis of paracoccidioidomycosis are presented.