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Titanium - castor oil based polyurethane composite foams for bone tissue engineering.

Research paper by Fernando Javier FJ Aguilar-Pérez, Rossana Faride RF Vargas-Coronado, José Manuel JM Cervantes-Uc, Juan J Valerio Cauich-Rodríguez, Raúl R Rosales-Ibañez, José Antonio JA Rodríguez-Ortiz, Yadir Y Torres-Hernández

Indexed on: 26 Jun '19Published on: 25 Jun '19Published in: Journal of biomaterials science. Polymer edition



Abstract

Polyurethanes (PU) foams with titanium particles (Ti) were prepared with castor oil (CO) and isophorone diisocyanate (IPDI) as polymeric matrix, and 1, 3 and 5 wt.% of Ti. Composites were physicochemically and mechanically characterized and their biocompatibility assessed using human dental pulp stem cells (HDPSC). PU synthesis was confirmed by FTIR, but the presence of Ti was detected by RAMAN, X-ray diffraction (peak at 2θ = 40.2º) and by EDX-mapping. Materials showed three decomposition temperatures between 300 °C and 500 ºC and their decomposition were not catalyzed by Ti particles. Compressive modulus (164-846 kPa), compressive strength (12.9-116.7 kPa) and density (128-240 kg/m) tend to increase with Ti concentration but porosity was reduced (87% to 80%). Composites' foams were fully degraded in acid and oxidative media while remained stable in distilled water. HDPSC viability on all composites was higher than 80% up to 14 days while proliferation dropped up to 60% at 21 days. Overall, these results suggest that these foams can be used as scaffolds for bone tissue regeneration.