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Tissue engineering in congenital diaphragmatic hernia.

Research paper by Dario O DO Fauza

Indexed on: 06 Jul '14Published on: 06 Jul '14Published in: Seminars in Pediatric Surgery



Abstract

Engineered diaphragmatic repair is emblematic of perinatal regenerative medicine and of the fetal tissue engineering concept. The alternative of a cellularized graft for the repair of a congenital diaphragmatic defect in the neonatal period is both biologically justifiable by the mechanisms behind diaphragmatic hernia recurrence as well as an ideal match for fetal mesenchymal stem cell-based constructs. It has been among the most developed experimental pursuits in neonatal tissue engineering, of which clinical application should be forthcoming.