Tidal breathing technique for induction of anaesthesia with high concentration of sevoflurane, isoflurane or halothane in infants undergoing cardiac surgery

Research paper by U Kiran, N Saxena, N Raizada

Indexed on: 01 Dec '01Published on: 01 Dec '01Published in: Indian Journal of Thoracic and Cardiovascular Surgery


nduction characteristics of sevoflurane were compared with isoflurane and halothane in 45 acyanotic infants undergoing surgery for congenital heart disease.Infants were randomized into three groups of 15 each. None of them received premedication. In group I induction was done with 8% sevoflurane in 100% oxygen, in group II with 5% isoflurane in 100% oxygen and in group III with 4% halothane in 100% oxygen.Induction time, intubation time, haemodynamic variables and side effects like coughing, laryngospasm, breatholding and excessive crying were noted.The mean induction time taken as loss of eyelash reflex was significantly lower in sevoflurane group (52.80±8.5 seconds) as compared to isoflurane (196.80±49.13 seconds) and halothane groups (168.72±9.1 seconds) (p value <0.001). The mean intubation time in sevoflurane group was 2.97±0.48 minutes followed by halothane group (5.10±2.9 minutes) and isoflurane group (6.70±1.77 minutes) (p value < 0.001).The incidence of coughing and laryngospasm was observed in 6% (1 in 15), each in sevoflurane and halothane groups and 20% (3 in 15) cases in isoflurane group. Haemodynamics were comparable in both sevoflurane and isoflurane groups. However in halothane group significant decrease in mean arterial pressure was observed.Sevoflurane anaesthesia is a better alternative for induction in infants undergoing cardiac surgery as compared to isoflurane and halothane. (Ind J Thorac Cardiovasc Surg, 2001; 17:233-237)