Thiyl radicals and induction of protein degradation.

Research paper by Christian C Schöneich

Indexed on: 28 Jul '15Published on: 28 Jul '15Published in: Free radical research


Thiyl radicals are important intermediates in the redox biology and chemistry of thiols. These radicals can react via hydrogen transfer with various C-H bonds in peptides and proteins, leading to the generation of carbon-centered radicals, and, potentially, to irreversible protein damage. This review summarizes quantitative information on reaction kinetics and product formation, and discusses the significance of these reactions for protein degradation induced by thiyl radical formation.