Thionylation of 5-alkyl-3H-furan-2-ones and their non-cyclic 4-oxoalkanoate ester analogs

Research paper by A. Yu. Egorova, V. A. Sedavkina, N. A. Morozova

Indexed on: 01 Jan '99Published on: 01 Jan '99Published in: Chemistry of Heterocyclic Compounds


We have studied thionylation of 5-R-3H-furan-2-ones and 4-oxoalkanoates using phosphorus pentasulfide and the Lawesson reagent. It was found that the structure of the reaction products dependent on the thionylating agent. Preparative methods have been developed for the synthesis of 5-R-5H- and 5-R-3H-thiophen-2-ones and 5-R-3H-furan-2-thiones.