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The use of Tofacitinib in the treatment of inflammatory bowel disease.

Research paper by E L EL Nasonov, D I DI Abdulganieva, I F IF Fairushina

Indexed on: 18 May '19Published on: 17 May '19Published in: Terapevticheskii arkhiv



Abstract

Major advances in pharmacology of the 21st century include the development of a new class of drugs, which are low-molecular, chemically synthesized molecules (the so-called "small molecules"), the point of application of which is Janus kinase (Janus kinase, JAK) involved in intracellular cytokine signaling. The review examines the molecular aspects of the JAK-STAT signaling pathway, justifying the use of the JAK-kinase inhibitor (tofacitinib) in the treatment of inflammatory bowel disease.