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The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma.

Research paper by Adrian J AJ Frank, Roberto R Hernan, Andrew A Hollander, Janet C JC Lindsey, Meryl E ME Lusher, Christine E CE Fuller, Steven C SC Clifford, Richard J RJ Gilbertson

Indexed on: 19 Feb '04Published on: 19 Feb '04Published in: Brain research. Molecular brain research



Abstract

We analyzed the TP53 and INK4A/ARF loci in 29 pediatric medulloblastomas. Mutually exclusive mutation in TP53, methylation of P14(ARF) or deletion of INK4A/ARF were identified in 21% (6/29) of tumors. Five of these alterations were detected in large cell/anaplastic medulloblastomas or tumors with significant anaplasia. Our data provide the first evidence that alterations within the TP53-ARF tumor suppressor pathway contribute to development of aggressive forms of medulloblastoma.

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