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The see-saw of Keap1-Nrf2 pathway in Cancer

Research paper by Poorti Pandey, Alok Kumar Singh, Mritunjai Singh, Mallika Tewari, Hari Shankar Shukla, Indrajeet Singh Gambhir

Indexed on: 10 Mar '17Published on: 07 Feb '17Published in: Critical Reviews in Oncology/Hematology



Abstract

Keap1-Nrf2 pathway is continuously involved in the cytoprotection from oxidative stress generated due to various factors either extrinsic or intrinsic in origin. This role of Nrf2 in the response to oxidative stress is well established. Following oxidative insult, Nrf2 mediates the regulation of the inducible expression of cytoprotective genes. The level and functional capacity of Nrf2 is regulated at the post-transcriptional level, mainly through its association with an actin-associated protein, Keap1. Various studies reported that any discrepancy from their routine may lead to promotion of tumor as well. So there is need to explore their role in cytoprotection and tumor promotion if any. This review is an attempt to critically analyze the available data that may lighten up the present knowledge and unveil the new regime for cancer prevention and treatment.