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The role of RhoA/Rho kinase pathway in endothelial dysfunction.

Research paper by Lin L Yao, Maritza J MJ Romero, Haroldo A HA Toque, Guang G Yang, Ruth B RB Caldwell, R William RW Caldwell

Indexed on: 26 Jan '11Published on: 26 Jan '11Published in: Journal of cardiovascular disease research



Abstract

Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.