The prognostic value of a trend in modified SOFA score for patients with hematological malignancies in the intensive care unit.

Research paper by Astrid A M P AAMP Demandt, Daniël A DA Geerse, Bram J P BJP Janssen, Bjorn B Winkens, Harry C HC Schouten, Walther N K A WNKA van Mook

Indexed on: 29 Jun '17Published on: 29 Jun '17Published in: European Journal of Haematology


Patients with hematological malignancies admitted to an intensive care unit (ICU) have a poor prognosis. The Sequential Organ Failure Assessment (SOFA) score is used to monitor patients on the ICU. Little is known about the value of this score in hematology patients. Therefore, the prognostic value of the SOFA score and a modified hematological SOFA score (SOFAhem) was studied.Patients with hematological malignancies admitted to the ICU between 1999 and 2009 were analyzed in a retrospective cohort study. The SOFAhem score was defined as the original SOFA score omitting the coagulation and neurological parameters.In 149 admissions, ICU mortality was 52%. Mortality was significantly associated with higher SOFA and SOFAhem scores on admission, and trend in SOFAhem scores. An unchanged and increased SOFAhem score compared to decreasing SOFAhem scores were associated with a higher mortality rate (53% resp 67% resp 25%).Trends in SOFA or SOFAhem score are both suitable as prognostic parameter. The trend in SOFAhem score seems to be independently related to mortality in hematological patients admitted to the ICU and because of the higher odds ratios and lower p-values compared to the SOFA score it is probably stronger related to mortality than the classical score, but its prognostic value should be tested in a larger cohort. This article is protected by copyright. All rights reserved.