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[The preoperative and postoperative changes of T lymphocyte subsets and TNF in patients with locally advanced lung cancer.].

Research paper by B B Zhang, Y Y Wu

Indexed on: 25 Dec '99Published on: 25 Dec '99Published in: Zhongguo fei ai za zhi = Chinese journal of lung cancer



Abstract

To study the immunologic significance of surgical resection for patients with locally advanced lung cancer.The levels of the subsets of the peripheral blood T lymphocytes (CD3 , CD4 , CD8) and the serum tumor necrosis factor (TNF) were detected in 15 patients with locally advanced lung cancer before operation and on the 10th day and the 17th after operation by indirect immunofluorescence technique and enzyme linked immunosorbent assay (ELISA) respectively.(1)The subsets of T lymphocytes in patients with lung cancer were remarkably abnormal before operation. The CD3 score and CD4/ CD8 ratio in the cancer cases were significantly lower than those in the abnormal adults ( P < 0. 05) , but the CD8 and level of serum TNF significantly higher than those in the control group ( P < 0. 05) . (2)The CD3 score and CD4/ CD8 ratio on the 17th postoperative day were significantly higher than those before operation in the cancer patients ( P < 0. 05) , but the CD8 significantly lower than that before operation ( P < 0. 05) . The level of serum TNF on the 17th postoperative day was significantly lower than that before operation ( P < 0. 05) too.(1)The cellular immunobalance of the patients could be recovered by surgical treatment. (2)From the immunologic point of view , the surgical resection for locally advanced lung cancer shows active significance.