The origin of Hypertriglyceridemia in streptozotocin diabetic rats

Research paper by J. D. Schnatz, J. M. Formaniak, C. Chlouverakis

Indexed on: 01 Apr '72Published on: 01 Apr '72Published in: Diabetologia


The effect of diet on the origin of hypertriglyceridemia seen in experimental diabetes was studied in streptozotocin diabetic rats after insulin treatment for one month and two days after insulin withdrawal. The data indicate that both exogenous and endogenous types of hypertriglyceridemia were present in insulin treated streptozotocin diabetes but that the exogenous component predominated during the period of insulin treatment and was independent of the amount of dietary fat. After insulin withdrawal there was a rise in serum triglyceride which was mainly reflected in the endogenous component. The data imply that dietary sucrose or protein might have contributed to this endogenous hypertriglyceridemia.