The KK-Periome database for transcripts of periodontal ligament development.

Research paper by Masahiro M Saito, Eisaku E Nishida, Takashi T Sasaki, Toshiyuki T Yoneda, Nobuyoshi N Shimizu

Indexed on: 10 Jan '09Published on: 10 Jan '09Published in: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution


The periodontal ligament (PDL) is a strong connective tissue that surrounds the tooth root, absorbs occlusal forces, and functions as a sense organ. PDL originated from dental follicle (DF), which possessed mesenchymal progenitors in the developing tooth germ. However, as specific marker genes for PDL and DF are currently unavailable, the molecular mechanisms of PDL development are yet to be clarified. To facilitate the identification of such genes, we have previously established a transcriptome database of the human PDL (the KK-Periome database) and screened for specific genes expressed during PDL development. Initial screening of the database revealed two marker genes for distinguishing DF and PDL. The KK-Periome database thus appears to offer a useful resource for investigating genes involved in PDL development.