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The Influence of Condensed Cycle on Regiochemistry of Electrophilic Heterocyclization of 3-Alkenyl-2-Thioxopyrimidin-4-One by p-Alkoxyphenyltellurium Trichloride

Research paper by Mykola Kut, Mikhajlo Onysko, Vasil Lendel

Indexed on: 06 Feb '18Published on: 05 Feb '18Published in: Journal of Heterocyclic Chemistry



Abstract

Electrophilic heterocyclization of 5-alkenyl-1-methyl-6-thioxopyrazolo[3,4-d]pyrimidin-4-ones and 3-alkenyl-2-thioxoquinazoline-4-ones under the action of p-alkoxyphenyltellurium trichloride leads to annulation of thiazoline cycle with formation of 7-[(p-alkoxyphenyl)telluromethyl]-1-methyl-6,7-dihydropyrazolo[3,4-d][1,3]thiazolo[3,2-a]pyrimidin-4(1H)-ones hydrochlorides and 2-(p-alkoxyphenyl)dichlorotelluromethyl-2,3-dihydro-5H-[1,3]thiazolo[2,3-b]quinazolin-5-ones hydrochlorides. Reduction of salts by the action of excess of sodium sulfite leads to formation of arylhetaryl telluride.