The Independent Association of Non-Alcoholic Fatty Liver Disease with Lower Urinary Tract Symptoms/ Benign Prostatic Hyperplasia and Erectile Function Scores.

Research paper by Huseyin H Eren, Mustafa Ozan MO Horsanali

Indexed on: 01 Jun '15Published on: 23 Mar '19Published in: BJU International


To evaluate the association between non-alcoholic fatty liver disease and Lower urinary tract symptoms/ Benign prostate hyperplasia and erectile function scores. Totally 356 men diagnosed with LUTS/ BPH were evaluated retrospectively between January 2016 and March 2018. Anthropometric and laboratory characteristics were collected. According to the liver echogenicity degree, patients were divided into four groups: grade 0 was normal; NAFLD grades 1 to 3 had increasing fat. LUTS symptoms, PSA levels, prostate volumes (PV) and IIEF-5 were compared statistically between NAFLD grades. PSA levels did not differ between groups. IPSS, PV and post-voided residual urine (PVRU) were significantly higher in NAFLD grades. Conversely, Q max, and IIEF score were lower in patients with increased NAFLD grades. NAFLD grade rather than having metabolic syndrome (MetS) positive affected prostate parameters and IIEF. NAFLD correlated positively with IPSS, PV and PVRU, whereas a negative correlation existed Q max and IIEF. Age and NAFLD were the independent predictor of IPSS, PV, Q max, PVRU volume on multivariate analysis. We documented that NAFLD was an independent predictive factor for IPSS, PV, Q max, PVRU and IIEF. MetS was a significant predictive factor for only IIEF, so that NAFLD may identify high risk for LUTS better than MetS. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

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