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The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes.

Research paper by Maria M Saumoy, Miguel M López-Dupla, Sergi S Veloso, Carlos C Alonso-Villaverde, Pere P Domingo, Montserrat M Broch, Merce M Miranda, Blai B Coll, Amadeu A Saurí, Joan J Vendrell, Cristóbal C Richart, Francesc F Vidal

Indexed on: 23 Apr '08Published on: 23 Apr '08Published in: AIDS (London, England)



Abstract

We determined the IL-6 -174 G>C single nucleotide polymorphism, IL-6 mRNA expression in subcutaneous adipose tissue (SAT) and IL-6 plasma levels in HIV-1-infected patients with and without lipodystrophy and uninfected controls. HIV-1-infected patients had a greater prevalence of the IL-6 -174 C/C genotype and the C allele, higher SAT IL-6 mRNA expression and plasma IL-6 levels than controls. The IL-6 -174 G>C genotype distribution and allele frequencies, SAT IL-6 mRNA expression and IL-6 plasma levels were non-significantly different between HIV-1-infected patients with and without lipodystrophy.

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