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The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, (99m)Tc) radiopharmaceuticals.

Research paper by Tanushree T Ganguly, Benjamin B BB Kasten, Dejan-Krešimir DK Bučar, Leonard R LR MacGillivray, Clifford E CE Berkman, Paul D PD Benny

Indexed on: 03 Nov '11Published on: 03 Nov '11Published in: Chemical Communications



Abstract

Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)(3) (M = Re, (99m)Tc) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.