The effect of chlorpromazine on haemostasis

Research paper by Allen B. Dobkin, Lyman M. Fisher, Gordon M. Wyant

Indexed on: 01 Oct '57Published on: 01 Oct '57Published in: Canadian Anaesthetists' Society journal


A study of the effect of chlorpromazine on the haemostatic mechanism was carried out on thirteen adult male patients in relatively good general health and who were under the stress of preparation for an operation. A reduction in blood pressure indicated a significant decrease in peripheral vascular control, and a decrease in the prothrombin time occurred in most of the patients. These changes did not persist into the postoperative peiiod. Under these clinical conditions and by this technique of study, it was found that chlorpromazine may decrease the coagulability during operation and may increase coagulability postoperatively. The cause of these changes was not revealed