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The effect of aspalatone, a new antithrombotic agent, on the specific activity of antioxidant enzyme in the rat blood

Research paper by Chin Kim, Chang-Hui Koo, Dong-Young Choi, Yong-Joon Cho, Jae-Ho Choi, Doo-Hyeon Im, Wang-Kee Jhoo, Hyoung-Chun Kim

Indexed on: 01 Oct '96Published on: 01 Oct '96Published in: Archives of Pharmacal Research



Abstract

The antioxidant efficacy of aspalatone, a new antithrombotic agent, has been recognized in the neurotoxic model and in the cardiotoxic model in preliminary studies. We examined the specific activity of antioxidant enzyme in the rat blood following administrations of aspirin, maltol, aspirin together with maltol, salicylmaltol (major metabolite of aspalatone) and aspalatone, respectively. Our assessment showed that salicylmaltol, maltol, aspalatone enhanced antiperoxidative activity. In addition, neither aspirin nor combination of aspirin and maltol, showed any significant effect on the activity of antioxidant enzyme. Because H2O2 accumulation may stimulate the thrombogenesis in blood, the result suggests that the induction of blood antiperoxidative activity produced by aspalatone may have beneficial effects on the thrombogenesis.