The Dilemma of Breast Cancer Treatment and Existing Collagen Vascular Disease: A Case of Scleroderma and Review of the Literature

Research paper by Nicole M. Zaremba MD, Deimante Tamkus MD, Luciano DiCarlo DO, James Herman MD, Mersadies Martin MD, Harvey L. Bumpers MD

Indexed on: 29 Apr '16Published on: 28 Apr '16Published in: The Breast Journal


Collagen vascular diseases present a treatment dilemma for patients with breast cancer. Due to the potential for severe, acute, and late complications of radiation therapy, a history of collagen vascular disease (CVD) is a relative contraindication to breast‐conserving treatment. We present a case of early stage breast cancer in a patient with severe scleroderma treated with breast‐conserving surgery without radiation and a brief review of the published literature regarding the therapeutic approach to the patient with CVD and breast cancer.