The Context Organization of Functional Regions in Yeast Genes with High-Level Expression

Research paper by A. V. Kochetov, A. Sarai, D. G. Vorob'ev, N. A. Kolchanov

Indexed on: 01 Nov '02Published on: 01 Nov '02Published in: Molecular Biology


With the example of yeast genes, context organization was compared for functional gene regions (promoter, 5"-UTR, 3"-UTR) and tested for association with the level of gene expression. Several parameters (nucleotide composition, dinucleotide content bias) proved to correlate with expression level, each functional region having its specific features. Context optimization of a functional region was assumed to be essential for highly efficient interaction with the expression system of the cell. Specific context features were considered as dispersed signals important for high-level gene expression.