The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases.

Research paper by Verena Katharina VK Raker, Christian C Becker, Kerstin K Steinbrink

Indexed on: 12 Apr '16Published on: 12 Apr '16Published in: Frontiers in immunology


Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent regulator of innate and adaptive immune cell functions. Therapeutic strategies to interrupt or enhance cAMP generation or effects have immunoregulatory potential in autoimmune and inflammatory disorders. Here, we provide an overview of the cyclic AMP axis and its role as a regulator of immune functions and discuss the clinical and translational relevance of interventions with these processes.