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The ATA Guidelines on Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of eFVPTC without Invasion to NIFTP.

Research paper by Bryan R BR Haugen, Anna M AM Sawka, Erik K EK Alexander, Keith C KC Bible, Patrizio P Caturegli, Gerard G Doherty, Susan J SJ Mandel, John C JC Morris, Aziza A Nassar, Furio F Pacini, Martin M Schlumberger, Kathryn G KG Schuff, Steven I SI Sherman, Hilary H Somerset, Julie Ann JA Sosa, et al.

Indexed on: 25 Jan '17Published on: 25 Jan '17Published in: Thyroid : official journal of the American Thyroid Association



Abstract

American Thyroid Association (ATA) leadership asked the ATA Thyroid Nodules and Differentiated Thyroid Cancer Guidelines Task Force to review, comment on and make recommendations related to the suggested new classification of Encapsulated Follicular Variant Papillary Thyroid Carcinoma (eFVPTC) without capsular or vascular invasion to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). The task force consists of members from the 2015 guidelines task force with the recusal of three members who were authors on the paper under review. Four pathologists and one endocrinologist were added for this specific review. We assessed the manuscript proposing the new classification and related literature. We recommend that the histopathologic nomenclature for Encapsulated Follicular Variant Papillary Thyroid Carcinoma (eFVPTC) without invasion may be re-classified as a NIFTP given the excellent prognosis of this neoplastic variant. This is a weak recommendation based on moderate-quality evidence. We also note that retrospective studies are needed to validate the observed patient outcomes (and test performance in predicting thyroid cancer outcomes), as well as implications on patients' psychosocial health and economics.