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The application of terahertz pulsed imaging in characterising density distribution of roll-compacted ribbons

Research paper by Jianyi Zhang, Chunlei Pei, Serena Schiano, David Heaps, Chuan-Yu Wu

Indexed on: 19 Mar '16Published on: 27 Jan '16Published in: European Journal of Pharmaceutics and Biopharmaceutics



Abstract

Roll compaction is a commonly used dry granulation process in pharmaceutical, fine chemical and agrochemical industries for materials sensitive to heat or moisture. The ribbon density distribution plays an important role in controlling properties of granules (e.g. granule size distribution, porosity and strength). Accurate characterisation of ribbon density distribution is critical in process control and quality assurance. The terahertz imaging system has a great application potential in achieving this as the terahertz radiation has the ability to penetrate most of the pharmaceutical excipients and the refractive index reflects variations in density and chemical compositions. The aim of this study is to explore whether terahertz pulse imaging is a feasible technique for quantifying ribbon density distribution.

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