TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction.

Research paper by Jiaxing J Hu, Hua-Li HL Qin, Wengang W Xu, Junli J Li, Fanglin F Zhang, Hua H Zheng

Indexed on: 06 Nov '14Published on: 06 Nov '14Published in: Chemical Communications


A convenient metal-free method for the synthesis of 3-aryl isoindolinones via TfOH catalyzed aromatic C-H functionalization of electron-rich arenes with 2-formylbenzonitriles is developed. This process provided a new efficient strategy for the synthesis of isoindolinone derivatives in good to high yields and regioselectivities by forming two bonds.