Synthesis, structure, and anticholinesterase activity of some organophosphorus derivatives of anabasine

Research paper by D. N. Dalimov, M. B. Gafurov, F. G. Kamaev, A. A. Abduvakhabov

Indexed on: 01 Jul '87Published on: 01 Jul '87Published in: Chemistry of Natural Compounds


Anabasine derivatives based on methylphosphonothoic acid have been synthesized. It has been shown by PMR spectroscopy that in solution O-alkyl O-[β-(anabasin-1-yl)ethyl] methylphosphonothioates exist in two stereomeric forms, which is due to the influence of the optically active anabasine residue. It has been shown that these compounds are competitive reversible inhibitors of acetylcholinesterase and of butyrylcholinesterase.