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Synthesis ofN-(2-hydroxyalkyl)-4-thiazolidinones from oxazolidines

Research paper by B. F. Kukharev, V. K. Stankevich, G. R. Klimenko

Indexed on: 01 Dec '97Published on: 01 Dec '97Published in: Russian Chemical Bulletin



Abstract

The reaction of oxazolidines with mercaptoacetic acid affordsN-(2-hydroxyalkyl)-4-thiazolidinones in 58–87% yield regardless of the position of the oxazolidine—iminoalcohol tautomeric equilibrium. The structures of the resulting compounds were confirmed by IR and1H NMR spectroscopy.