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Synthesis of the C1-C23 fragment of Spirastrellolide A.

Research paper by Jin-Haek JH Yang, Jia J Liu, Richard P RP Hsung

Indexed on: 20 May '08Published on: 20 May '08Published in: Organic Letters



Abstract

Synthesis of the C1-C23 fragment in spirastrellolide A is described, featuring a cyclic acetal-tethered RCM for stereoselective constructions of spiroketal, and a 1,3- anti aldol involving methyl ketone enolate and Mukaiyama conditions.