Synthesis of Substituted Esters of Ursolic, Betulonic, and Betulinic Acids Containing the Nitroxyl Radical 4-Amino-2,2,6,6-Tetramethylpiperidine-1-Oxyl

Research paper by S. A. Popov, A. V. Shpatov, I. A. Grigor’ev

Indexed on: 11 Feb '15Published on: 11 Feb '15Published in: Chemistry of Natural Compounds


Reaction of ursolic, betulonic, and betulinic acids with 1-oxyl-2,2,6,6-tetramethylpiperidin-4-ylamino-2-chloroacetate in the presence of K2CO3 formed substituted esters of the triterpene acids with the nitroxyl radical 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl. The biological activity of the synthesized derivatives was studied.