Synthesis of some derivatives of 3'-C-methyl pyrimidine nucleosides.

Research paper by Mohamed M Aljarah, Christophe C Mathé, Christian C Périgaud

Indexed on: 09 Sep '08Published on: 09 Sep '08Published in: Nucleic acids symposium series (2004)


Attempts for the synthesis of 2'-deoxy-2'-fluoro nucleoside derivative of 3'-C-methyluridine were reported. The corresponding parent nucleoside was chosen as the starting material. However, the 2'-deoxy-2'-fluoro nucleoside was not obtained. Nevertheless, the new and unexpected nucleoside derivatives obtained as well as some proposals of mechanism regarding their formation will be presented.

More like this: