Synthesis of purine and 2-aminopurine conjugates bearing the fragments of heterocyclic amines at position 6

Research paper by Dmitry A. Gruzdev, Vera V. Musiyak, Evgeny N. Chulakov, Galina L. Levit, Victor P. Krasnov

Indexed on: 24 Sep '15Published on: 24 Sep '15Published in: Chemistry of Heterocyclic Compounds


A series of novel N-(purin-6-yl)- and N-(2-aminopurin-6-yl) derivatives of heterocyclic amines was synthesized. It was found that preferred preparative method for N-(purin-6-yl) derivatives of heterocyclic amines is interaction of 6-chloropurine with heterocyclic amines without any catalyst; whereas N-(2-aminopurin-6-yl) derivatives were obtained in the moderate-to-high yields while heating 2-amino-6-chloropurine and heterocyclic amines in water in the presence of sulfuric acid.