Synthesis of Novel 4,4-Dialkyl- and 4,4-Diarylindeno[1,2-b]Thiophenes and their 2-Bromo Derivatives*

Research paper by J. Bucevicius, P. Adomenasp, S. Tumkevicius

Indexed on: 20 Dec '14Published on: 20 Dec '14Published in: Chemistry of Heterocyclic Compounds


A series of new 4,4-dialkyl- and 4,4-diaryl-4H-indeno[1,2-b]thiophenes and their 2-bromo derivatives were synthesized and characterized. An economical one-pot method for the preparation of the key starting material 2-(2-thienyl)benzoic acid and improved procedures for the synthesis of indeno[1,2-b]thiophen-4-one and 4,4-dialkyl-4H-indeno[1,2-b]thiophenes have been developed. The described methods were shown to be efficient for the preparation of the title compounds on a multigram scale.