Synthesis of azinylthioureas and their heterocyclization using α-chloroacetoacetic ester

Research paper by V. V. Dovlatyan, K. A. Eliazyan, E. A. Ghazaryan, A. P. Yengoyan

Indexed on: 01 Mar '06Published on: 01 Mar '06Published in: Chemistry of Heterocyclic Compounds


Treatment of aminopyrimidines with a mixture of PhCOCl and NH4SCN and subsequent debenzoylation of the N-benzoyl-N′-(4,6-substituted pyrimidin-2-yl)thioureas obtained gave pyrimidinyl-2-thioureas. The heterocyclization of the azinyl-2-thioureas with α-chloroacetoacetic ester gave ethyl 2-(4,6-substituted azin-2-yl)aminothiazole-5-carboxylates.