Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates.

Research paper by Amanda J AJ Krzysiak, Animesh V AV Aditya, James L JL Hougland, Carol A CA Fierke, Richard A RA Gibbs

Indexed on: 17 Dec '09Published on: 17 Dec '09Published in: Bioorganic & Medicinal Chemistry Letters


Proteins bearing a CaaL sequence are typically geranylgeranylated to enable their proper localization and function. We found that many of the dansyl-GCaaL peptides representing mammalian CaaL proteins can be farnesylated by FTase. This result may have important implications for prenylated protein biology.