Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles.

Research paper by Dalip D Kumar, N Maruthi NM Kumar, Kuei-Hua KH Chang, Ritika R Gupta, Kavita K Shah

Indexed on: 30 Aug '11Published on: 30 Aug '11Published in: Bioorganic & Medicinal Chemistry Letters


A series of 3,5-bis(indolyl)-1,2,4-thiadiazoles were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-thiocarboxamide 3 with iodobenzene diacetate underwent oxidative dimerization to give 3,5-bis(indolyl)-1,2,4-thiadiazoles 4a-n. Among the synthesized bis(indoly)-1,2,4-thiadiazoles, the compound 4h with 4-chlorobenzyl and methoxy substituents showed the most potent activity.