Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens.

Research paper by Samer S SS Daher, Xiao X Jin, Jimmy J Patel, Joel S JS Freundlich, Bettina B Buttaro, Rodrigo B RB Andrade

Indexed on: 08 Jul '19Published on: 10 Apr '19Published in: Bioorganic & Medicinal Chemistry Letters


Novel antibacterial drugs that treat multidrug resistant pathogens are in high demand. We have synthesized analogs of solithromycin using Cu(I)-mediated click chemistry. Evaluation of the analogs using Minimum Inhibitory Concentration (MIC) assays against resistant Staphylococcus aureus, Escherichia coli, and multidrug resistant pathogens Enterococcus faecium and Acinetobacter baumannii showed they possess potencies similar to those of solithromycin, thus demonstrating their potential as future therapeutics to combat the existential threat of multidrug resistant pathogens. Copyright © 2019 Elsevier Ltd. All rights reserved.

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