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Supramolecular chemical shift reagents inducing conformational transitions: NMR analysis of carbohydrate homooligomer mixtures.

Research paper by Sophie R SR Beeren, Sebastian S Meier

Indexed on: 22 Jan '15Published on: 22 Jan '15Published in: Chemical Communications



Abstract

We introduce the concept of supramolecular chemical shift reagents as a tool to improve signal resolution for the NMR analysis of homooligomers. Non-covalent interactions with the shift reagent can constrain otherwise flexible analytes inducing a conformational transition that results in signal separation. Here we use this approach for the quantitative analysis of a complex homooligomeric glycan mixture.