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Sugar-bearing tetraphenylethylene: novel fluorescent probe for studies of carbohydrate-protein interaction based on aggregation-induced emission.

Research paper by Jin-Xiang JX Wang, Qi Q Chen, Ning N Bian, Fen F Yang, Jing J Sun, Ai-Di AD Qi, Chao-Guo CG Yan, Bao-Hang BH Han

Indexed on: 08 Feb '11Published on: 08 Feb '11Published in: Organic & Biomolecular Chemistry



Abstract

Neutral sugar-bearing tetraphenylethenes (TPE) are designed and prepared as "turn-on" luminescent sensors for lectins and glycosidases based on aggregation-induced emission. Through aggregation derived from carbohydrate-lectin binding, multivalent mannosyl-bearing TPE shows a good selectivity and sensitivity to Con A by switching on the fluorescence of water-soluble tetraphenylethylene-based glyco-conjugates in aqueous solution. Meanwhile, cellobiosyl-bearing TPE can be used to investigate enzymatic hydrolysis based on emission enhancing by glycosidase-induced aggregation.