Study of the fragmentation mechanism of novel functionalized macrocycles by Fourier transform ion cyclotron resonance mass spectrometry.

Research paper by Hui H Chen, Da-Ming DM Du, Wen-Ting WT Hua, Meiyu M He, Bin B Xin

Indexed on: 26 Aug '03Published on: 26 Aug '03Published in: Biological Mass Spectrometry


Liquid secondary ion mass spectrometry (L-SIMS) of six new functionalized macrocycles was investigated. All six compounds yielded abundant fragment ions and protonation molecular ions [M + H](+) under L-SIMS conditions. The proposed fragmentation mechanisms were supported by high-resolution accurate mass data from Fourier transform ion cyclotron resonance mass spectrometric and MS(n) experiments on using sustained off-resonance irradiation collision-induced dissociation.