Study of basic deuterium exchange in the series of 3-hydroxypyridine derivatives

Research paper by V. P. Lezina, A. U. Stepanyants, L. D. Smirnov, K. M. Dyumaev

Indexed on: 01 May '72Published on: 01 May '72Published in: Russian Chemical Bulletin


A study was made of the basic deuterium exchange of 3-hydroxypyridine and its alkyl derivatives. The constants for the rate of hydrogen exchange in the 2-, 6-, and 4-positions of the ring were determined, in which connection the 2-position of theβ-pyridinol ring proved to be the most reactive.The introduction of methyl groups into the ring increases the rate of deuterium exchange in the 2- and 6-positions of theβ-pyridinol ring.Deuterium exchange of the protons of the methyl groups of the substituents occurs under intense heating.