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Studies on the inactivation of glyceraldehyde-3-phosphate dehydrogenase by methylglyoxal

Research paper by G. Leoncini, M. Maresca, S. Ronchi, A. Bonsignore

Indexed on: 01 May '81Published on: 01 May '81Published in: Cellular and Molecular Life Sciences



Abstract

Glyceraldehyde-3-P dehydrogenase (E.C. 1.2.1.12) from rabbit muscle is rapidly inactivated by methylglyoxal following pseudo first-order kinetics. Substrate, as well as inorganic phosphate, affords protection, whereas NAD+ is ineffective. The arginine residue implicated in the reaction is probably the anion binding site of the phosphate group of the substrate.