Structure-toxicity relationships of selected nitrogenous heterocyclic compounds

Research paper by T. Wayne Schultz, Mariely Cajina-Quezada, James N. Dumont

Indexed on: 01 Sep '80Published on: 01 Sep '80Published in: Archives of Environmental Contamination and Toxicology


A series of eleven nitrogen-containing heterocyclic compounds, which may be potentially associated with aqueous effluents from coal conversion technologies, were examined to determine the relationships between theirn-octanol/H2O partition coefficients, molecular weights, boiling points, and their toxicity monitored as reproduction impairment toTetrahymena pyriformis. Toxicity increases linearly with increased partition coefficient, molecular weight, and boiling point. All of these parameters increase with increased alkyl and ring addition.