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Structure-activity studies of oxazolidinone analogs as RNA-binding agents.

Research paper by John J Means, Steven S Katz, Abhijit A Nayek, Rajaneesh R Anupam, Jennifer V JV Hines, Stephen C SC Bergmeier

Indexed on: 11 Apr '06Published on: 11 Apr '06Published in: Bioorganic & Medicinal Chemistry Letters



Abstract

We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones.