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Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists.

Research paper by Hongyu H Zhao, Zhili Z Xin, Jyoti R JR Patel, Lissa T J LT Nelson, Bo B Liu, Bruce G BG Szczepankiewicz, Verlyn G VG Schaefer, H Douglas HD Falls, Wiweka W Kaszubska, Christine A CA Collins, Hing L HL Sham, Gang G Liu

Indexed on: 23 Mar '05Published on: 23 Mar '05Published in: Bioorganic & Medicinal Chemistry Letters



Abstract

The structure-activity relationship studies on a series of tetralin carboxamide growth hormone secretagogue receptor (GHS-R) antagonists are discussed. It was found that certain 2-alkoxycarbonylamino substituted tetralin carboxamides are potent, selective, and orally bioavailable GHS-R antagonists.

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